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Direct conversion of epoxides into aziridines with N-arylphosphoramidates |
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| Authors: | Fabrizio Minicone Wendy J RogersJames FJ Green Mommna KhanGeoffrey MT Smith Christopher D Bray |
| Institution: | School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom |
| Abstract: | Treatment of terminal epoxides with N-arylphosphoramidate anions leads directly to N-aryl aziridines. Existing methods for this transformation employ either multi-step syntheses or an iminophosphorane in conjunction with a Lewis acid. The described method therefore presents an advantage in terms of brevity and atom economy. |
| Keywords: | Aziridine Epoxide Phosphoramidate Ring-opening Anion-relay |
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