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Hericirine,a novel anti-inflammatory alkaloid from Hericium erinaceum
Authors:Wei Li  Wei Zhou  Dong-Sung Lee  Sang Hee Shim  Youn-Chul Kim  Young Ho Kim
Institution:1. School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Republic of Korea;2. College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea;3. College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea
Abstract:A novel ergosterol conjunction-type alkaloid, hericirine (1), was isolated from the dried fruiting bodies of Hericium erinaceum. The overall framework of 1 was isolated, and combined with hericerin and ergosterol. Its structure was elucidated based on spectroscopic analysis using 1D and 2D NMR, IR and HRESIMS techniques. We found that hericirine significantly inhibited protein expression of iNOS and COX-2 and reduced NO, PGE2, TNF-α, IL-6 and IL-1β production in RAW264.7 cells exposed to LPS.
Keywords:Hericium erinaceum  Hericiaceae  Hericirine  Anti-inflammation
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