FeCl3-catalyzed efficient synthesis of di(5-methylfuran/thiophen-2-yl)isatin analogues |
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| Authors: | A Swetha G Santosh KumarA Sanjeeva Kumar HM Meshram |
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| Institution: | Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A simple, inexpensive, environmentally friendly, and high yield protocol is described for the synthesis of (5-methylfuran/thiophene-2-yl)isatin by the reaction of 2-methylfuran/2-methylthiophene with isatin/isatin imine in the presence of FeCl3. The present protocol is ideal for the direct introduction of 2-methylfuran/2-methylthiophene onto isatin at 3-position with complete regioselectivity. |
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| Keywords: | Isatin Isatin imine 2-Methylfuran 2-Methylthiophene FeCl3 |
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