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Platypodiol a novel clerodane diterpene from Baccharis platypoda |
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| Authors: | Carolina Paula de Souza Moreira Djalma Menezes de Oliveira Claudia Nunes dos Santos Carlos Leomar Zani Tania Maria de Almeida Alves |
| Institution: | 1. Laboratório de Química de Produtos Naturais, Centro de Pesquisas René Rachou—Fiocruz, Belo Horizonte, MG, Brazil;2. Serviço de Fitoquímica e Prospecção Farmacêutica, Fundação Ezequiel Dias, Belo Horizonte, MG, Brazil;3. Departamento de Química e Exatas, Universidade Estadual do Sudoeste da Bahia, Jequié, BA, Brazil |
| Abstract: | There is an urgent need for effective leishmanicidal drugs to replace or supplement those in current use. Our group has been bioprospecting many Brazilian plants looking for potential new ‘hits’ to combat leishmaniasis. We found that Baccharis platypoda was one of the Asteraceae species that displayed leishmanicidal activity. We now describe the isolation of the new clerodane diterpene (1), named platypodiol after its ethanolic leaf extract. Its structure was determined by detailed NMR and ESI-TOF/MS/MS experiments. Considering the few publications about this species, this result has increased the phytochemical knowledge about B. platypoda. |
| Keywords: | Baccharis platypoda Asteraceae Leishmania (L ) amazonensis Clerodane diterpene |
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