Synthetic study of gymnocin-A: synthesis of the ABC ring fragment |
| |
Authors: | Takeo Sakai Shingo MatsushitaShogo Arakawa Atsuko KawaiYuji Mori |
| |
Institution: | Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan |
| |
Abstract: | The synthesis of the ABC ring fragment of gymnocin-A is described. The key feature of this approach was the convergent BC ring formation using an oxiranyl anion coupling, which was followed by intramolecular Williamson ether synthesis and the reductive etherification of an α-acetoxy acetal. The five-membered A ring was then constructed on the seven-membered B ring by radical cyclization of a β-alkoxy acrylate derivative. |
| |
Keywords: | Marine natural product Gymnocin-A Polycyclic ether Oxiranyl anion Convergent synthesis |
本文献已被 ScienceDirect 等数据库收录! |