1,3-Addition of silyl enol ethers to nitrones catalyzed by mesoporous aluminosilicate |
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Authors: | Suguru Ito Yoshihiro KubotaMasatoshi Asami |
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Institution: | Department of Advanced Materials Chemistry, Graduate School of Engineering, Yokohama National University, Tokiwadai 79-5, Hodogaya-ku, Yokohama 240-8501, Japan |
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Abstract: | Mesoporous aluminosilicate (Al-MCM-41) was found to be an effective and reusable catalyst for 1,3-addition of silyl enol ethers to nitrones. The reaction proceeded under mild reaction conditions to afford the corresponding β-(siloxyamino)ketones in high yields. Furthermore, a unique chemoselectivity of a nitrone over an aldehyde and an acetal, which are more reactive toward silyl enol ether in the presence of Al-MCM-41 than a nitrone, was observed. |
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Keywords: | Al-MCM-41 Solid acid catalyst 1 3-Addition of nitrones Chemoselective reaction |
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