Total synthesis of AI-77-B |
| |
| Authors: | Maddimsetti Venkateswara Rao Batchu Venkateswara Rao Bokka Ramesh |
| |
| Institution: | 1. Organic & Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India;2. Analytical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| |
| Abstract: | A new stereoselective approach for the synthesis of AI-77-B has been described. Dihydroisocoumarin fragment was made in two routes using Heck reaction followed by oxidation of the olefin and LDA mediated reaction. The chiral amino acid moiety has been obtained from d-ribose involving Grignard reaction on ribosylimine. Finally, condensation of dihydroisocoumarin with acid fragment furnished the title target AI-77-B. |
| |
| Keywords: | Heck reaction LDA mediated reaction Dihydroisocoumarin Grignard addition Total synthesis of AI-77-B |
| 本文献已被 ScienceDirect 等数据库收录！ |
