Direct asymmetric aldol reaction co-catalyzed by l-proline and isothiouronium salts |
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Authors: | Eun Cho Taek Hyeon Kim |
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Affiliation: | School of Chemical Engineering, College of Engineering, Chonnam National University, Gwangju 500-757, Republic of Korea |
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Abstract: | An efficient, simple, and highly selective protocol for the direct asymmetric aldol reaction between cyclohexanone and aromatic aldehydes using l-proline as a chiral catalyst is reported. Catalytic amounts of achiral isothiouronium iodide salt 1d have been used for the first time as a co-catalyst for this reaction, which proved to be an excellent catalyst, producing good to excellent yields (up to 93%) with good stereoselectivities (up to 93:7 dr and 99% ee). These aldols are formed under solvent-free catalytic system, inside a standard laboratory refrigerator, and without stirring. |
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Keywords: | Aldol reaction Asymmetric catalysis Isothiouronium salt Solvent-free condition |
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