A new and efficient one-pot synthesis of 2-hydroxy-1,4-dihydrobenzoxazines via a three-component Petasis reaction |
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| Authors: | Louisa Chouguiat Raouf Boulcina Bertrand Carboni Albert Demonceau Abdelmadjid Debache |
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| Affiliation: | 1. Laboratoire de Synthèse des Molécules d’intérêts Biologiques, Université Constantine 1, 25000 Constantine, Algeria;2. Institut des Sciences Chimiques de Rennes, UMR 6226 CNRS-Université Rennes 1, Campus de Beaulieu, 35042 Rennes CEDEX, France;3. Laboratoire de Chimie Macromoléculaire et de Catalyse Organique, Université de Liège, 4000 Liège, Belgium |
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| Abstract: | The secondary amines synthesized by the reaction between 2-aminophenols and aromatic aldehydes, via the reduction of the corresponding imines, were employed in the synthesis of new 2-hydroxy-2H-1,4-benzoxazine derivatives through a one-pot Petasis multicomponent reaction in good to excellent yields. |
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| Keywords: | 2-Hydroxy-2H-1,4-benzoxazine Petasis reaction Secondary amines Multicomponent reaction |
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