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Direct metal-free O-arylation of Biginelli 4-aryl-6-methyl-pyrimidine-2(1H)-one derivatives using diaryliodonium salts |
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| Authors: | Prerana B Thorat Nitin A WaghmodeNandkishor N Karade |
| Institution: | Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, Maharashtra, India |
| Abstract: | 4-Aryl-6-methyl-pyrimidine-2(1H)-one scaffolds of Biginelli type were subjected to C–O cross-coupling reactions using symmetrical diaryliodonium salts under transition metal-free conditions to afford 2-aryloxy pyrimidine derivatives in good to excellent yields. |
| Keywords: | Biginelli reaction 4-Aryl-6-methyl-pyrimidine-2(1H)-one Heteroaryl ether C&ndash O cross-coupling Diaryliodonium salts |
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