A one-pot tandem synthesis of various 1,2-disubstituted benzimidazoles |
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| Authors: | Keng Yoon Yeong Mohamed Ashraf Ali Chee Wei Ang Soo Choon Tan Hasnah Osman |
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| Affiliation: | 1. Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia;2. New Drug Discovery Research, Department of Medicinal Chemistry, Alwar Pharmacy College, Alwar, Rajasthan 301030, India;3. New Drug Discovery Research, Department of Medicinal Chemistry, Sunrise University, Alwar, Rajasthan 301030, India;4. Department of Organic Chemistry, School of Chemical Sciences, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia |
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| Abstract: | A facile method to synthesize various 1,2-disubstituted benzimidazoles is developed. It is suggested that formation of a Meisenheimer adduct between the substrate, amine, and solvent aids the N-arylation process. The generality of the protocol is demonstrated by the efficient reactions involving numerous substituents ranging from electron-withdrawing groups to electron-donating groups. |
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| Keywords: | Substituted benzimidazoles Tandem synthesis Cycloaddition |
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