I2-mediated C3-formylation of indoles by tertiary amine and H2O |
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| Authors: | Bo Zhang Bin LiuJianbin Chen Jiehui WangMiaochang Liu |
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| Institution: | College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, PR China |
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| Abstract: | An I2-promoted 3-formylation of free (N–H) and N-substituted indoles with tetramethylethylenediamine (TMEDA) and H2O as the carbonyl source is achieved, providing 3-formylindole in moderate to excellent yields with good functional group tolerance. This procedure represents an exceedingly attractive alternative to the traditional formylation methods. |
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| Keywords: | Iodine 3-Formylindole Tertiary amine Iminium ion |
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