Tetrasubstituted pyrazinones derived from the reaction of praziquantel with N-bromosuccinimide |
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| Authors: | Qingjie Zhao Chunkai Wang Edward L Ezell Yuxiang Dong Jonathan L Vennerstrom |
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| Institution: | 1. University of Nebraska Medical Center, College of Pharmacy, 986025 Nebraska Medical Center, Omaha, NE, United States;2. University of Nebraska Medical Center, Eppley Institute for Research in Cancer, 986105 Nebraska Medical Center, Omaha, NE, United States |
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| Abstract: | When praziquantel was exposed to N-bromosuccinimide in the presence of ethanol, a tricyclic 3-bromo-1-ethoxy pyrazinone was formed. From this and the analogous 1,3-dibromopyrazinone, a small library of 3-alkylamino-1-ethoxy, 1,3-dialkoxy, 3-alkoxy-1-bromo, and 3-alkylamino-1-bromo substituted pyrazinones were synthesized in high yields. |
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| Keywords: | Praziquantel N-Bromosuccinimide Pyrazinone Piperazinone |
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