Multicomponent reactions in PEG-400: ruthenium-catalyzed synthesis of substituted pyrroles |
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| Authors: | Srivari Chandrasekhar,Vidyavathi Patro,Lahu N. Chavan,Rambabu Chegondi,René Gré e |
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| Affiliation: | 1. Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India;2. Université de Rennes 1, Institut des Sciences Chimiques de Rennes, CNRS UMR 6226, Avenue du Général Leclerc, 35042 Rennes Cedex, France |
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| Abstract: | An efficient and eco-friendly method for the synthesis of substituted pyrroles has been developed via ruthenium-catalyzed multicomponent reaction of ketone, amine, and ethylene glycol in PEG-400 as solvent medium without using any external ligand. The catalytic system and solvent can be recycled with the same, as well as different, ketones with minimum loss of Ru-catalyst activity. |
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| Keywords: | Pyrrole Multicomponent reaction Ruthenium Eco-friendly Polyethylene glycol (PEG-400) |
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