Convenient synthesis of N1-substituted orotic acid derivatives |
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| Authors: | Jeannette T. Bowler Caitlin R. ClausenDaniel J. Blackburn Weiming Wu |
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| Affiliation: | Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132, USA |
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| Abstract: | A convenient and efficient method for the synthesis of N1-substituted orotic acid derivatives is reported. The synthetic route utilizes substituted maleimide as synthetic intermediate and takes only four simple steps from readily available starting materials. As a result, orotic acid derivatives with various alkyl and aromatic groups at N1 can be readily synthesized. |
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| Keywords: | Orotic acid Orotidine Synthesis Maleimide Bromomaleimide Dibromosuccinimide |
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