Efforts towards the synthesis of microsporin B: ready access to both the enantiomers of the key amino acid fragment |
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Authors: | Pandrangi Siva Swaroop Sibanarayan Tripathy Gorakhnath JachakD. Srinivasa Reddy |
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Affiliation: | CSIR-National Chemical Laboratory, Division of Organic Chemistry, Dr. Homi Bhabha Road, Pune 411008, India |
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Abstract: | Both the isomers methyl-(2S,8R)-2-((tert-butoxycarbonyl)amino)-8-hydroxydecanoate and methyl-(2S,8S)-2-((tert-butoxycarbonyl)amino)-8-hydroxydecanoate of an unusual amino acid residue and the key fragment of microsporin B are prepared. The key steps include cross metathesis and enzymatic kinetic resolution. In addition, a linear tetrapeptide with desired components towards total synthesis is also reported. |
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Keywords: | HDAC inhibitor Microsporin Cross metathesis Enzymatic resolution Tetrapeptide |
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