Control of metal coordination number in de novo designed peptides through subtle sequence modifications |
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Authors: | Lee Kyung-Hoon Matzapetakis Manolis Mitra Soumya Marsh E Neil G Pecoraro Vincent L |
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Institution: | Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA. |
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Abstract: | Substitution of an alanine for leucine (shown in light blue) in the hydrophobic interior of designed three-stranded coiled coils allows for the control of metal ion coordination number and geometry. The influence of this perturbation by a noncoordinating residue can be monitored by the dramatic impact on the 113Cd NMR spectrum. The structural effect occurs even when the residue substitution is as much as 7 A from the metal binding site. |
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