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Study on analysis of153Sm-EDTMP stability in vitro and vivo by HPLC |
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| Authors: | H Sh Bai H X Jin H Q Fan J Du F Wang D M Chen Zh Cheng |
| Institution: | (1) Department of Isotope, China Atomic Energy Institute, P. O. Box 275(58), 102413 Beijing, P. R. China;(2) MAP Medical Technologies Oy, Elementtitie 27, FIN-41160 Tikkakosi, Finland;(3) 1205 University Ave., Apt 316, 65201 Columbia, MO, USA |
| Abstract: | The behavior of153Sm-EDTMP in vitro and vivo is analyzed by the size exclusion HPLC. The experimental results show that EDTMP amounts have an obvious effect on the stability in vitro and uptake of153Sm-EDTMP in the liver. HPLC analysis of urine sample indicates that153Sm-EDTMP es excreted in the original form. The behavior in vivo of153Sm-EDTMP containing 4 μg is similar to that of153Sm-EDTMP containing 50 μg EDTMP at 1 h post-injection. |
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