Isoagatholactone,a diterpene of a new structural type from the sponge Spongia officinalis |
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| Authors: | G Cimino D De Rosa S De Stefano L Minale |
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| Institution: | Laboratorio per la Chimica e Fisica di Molecole di Interesse Biologico del C.N.R., Via Toiano, 2, Arco Felice, Napoli, Italy |
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| Abstract: | A new diterpene, isoagatholactone, isolated from the sponge Spongia officinalis, is the first natural compound with the carbon skeleton of isoagathic acid (2), the acid-catalyzed cyclization product of agathic acid (1). Structure 4 was assigned to isoagatholactone on spectral grounds and chemical correlation with grindelic acid (5). |
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