Thiosteroids—XXXV : Diastereomers of steroidal thiolsulfinates |
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| Authors: | M. Kishi S. Ishihara T. Komeno |
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| Affiliation: | Shionogi Research Laboratory, Shionogi & Co., Ltd., Fukushima-ku, Osaka, 553, Japan |
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| Abstract: | 17β-Hydroxy-5α-androstan-2α,3α-anti(R)-episulfoxide on treatment with methanol and ethanol in the presence of a trace amount of sulfuric acid gave diastereomers of bis((2β-methoxy- and 2β-ethoxy-17β-hydroxy-5α-androstan-3α-yl) disulfide S-monoxides respectively. The absolute configuration of the compounds was established by their Grignard reactions leading to diastereomeric phenyl sulfoxides stereoaspecifically. |
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