Studies on the syntheses of heterocyclic compounds—DXLVIII : Synthesis of a hasubanan ring system from the benzylisoquinoline reticuline |
| |
| Authors: | T Kametani T Kobari K Shishido K Fukumoto |
| |
| Institution: | Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, Japan |
| |
| Abstract: | The synthesis of a cepharamine analogue (19) from reticuline (1) by phenolic oxidation is reported. Reticuline was converted into the methine base (13b), whose dihydro compound (14c) was oxidised to the seco-morphinandienone (17b). Michael-type cyclization of 17b, followed by an isomerization of the enone (18) gave the cepharamine-type compound (19). |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
