Condensation of 1,4-diacetylpiperazine-2,5-dione with aldehydes |
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Authors: | C Gallina A Liberatori |
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Institution: | Centro di Studio per la Chimica del Fannaco del CNR, Istituto di Chimica Farmaceutica dell''Università, 00185 Roma, Italy |
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Abstract: | Condensation of 1,4-diacetylpiperazine-2,5-dione with aldehydes has been applied to the synthesis of albonoursin and unsymmetrical 3,6-diarylidenepiperazine-2,5-diones. The reaction has been extended to 1,4-diacetyl-3,6-dimethylpiperazine-2,5-dione, which gives derivatives of 2-methyl-3- phenylserine. The mechanism and stereochemistry are discussed; cis 1-acetyl-3-isobutylidene- piperazine-2,5-dione has been isolated. |
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