Studies on lactams—XXX : Synthesis of dihydropyrroles and tetrahydropyridines as intermediates for bicyclic β-lactams |
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| Authors: | AK Bose JL Fahey MS Manhas |
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| Institution: | Department of Chemistry and Chemical Engineering, Stevens Institute of Technology, Hoboken, New Jersey 07030, U.S.A. |
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| Abstract: | N-Acetyl derivatives of 5,6 or 7-membered lactams were condensed with aromatic aldehydes, deacetylated and allowed to react with P2S5 in refluxing pyridine. The thio-lactams so obtained were methylated with MeI to give 5- and 6-membered thioimidates which were convenient intermediates for the synthesis of penam and cepham derivatives. |
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