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| Apoptotic Effects of Hypocrellin A on HeLa Cells | |
| 作者姓名： | FEI Xiao-fang CHEN Jie ZHENG Ke-yan WU Wei SUN Su-juan WANG Li MA Lan LI Cong TENG Li-rong |
| 作者单位： | FEI Xiao-fang~ 1，2，CHEN Jie~1，ZHENG Ke-yan~3，WU Wei~1，SUN Su-juan~ 4，WANG Li~ 5，MA Lan~6，LI Cong~7 and TENG Li-rong~ 1** 1. College of Life Sciences，Jilin University，Changchun 130012，P. R. China; 2. Key Laboratory of Excited State Physics Process，Chinese Academy of Sciences，Changchun 130022，P. R. China; 3. Department of Chemistry，Jilin University，Changchun 130012，P. R. China; 4. Changchun Terumo Medical Products {Co.，} Ltd.，Changchun 130000，P. R. China; 5. Jilin Province Xidian Pharmaceutical Sci-tech Development {Co.，} Ltd.，Changchun 130000，P. R. China; 6. Department of Biology，Yunnan University，Kunming 650091，P. R. China; 7. Department of Chemistry，Yunnan University，Kunming 650091，P. R. China |
| 基金项目： | Supported by the Department of Science and Technology of JUin Province（No. 20020502）. |
| 摘 要： | IntroductionApoptosis plays an important role in multiple phy-siological and pathological processes, such as the em-bryonic maturation of the immune system, neurologicaldegeneration and so on. Because cervical cancer is amajor cause of death among women i… |
| 关 键 词： | 海拉细胞 Hypocrellin A 内分泌 癌细胞 宫颈癌 |
| 文章编号： | 1005-9040（2006）-06-772-04 |
| 收稿时间： | 2005-09-07 |
Apoptotic Effects of Hypocrellin A on HeLa Cells |
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| FEI Xiao-fang CHEN Jie ZHENG Ke-yan WU Wei SUN Su-juan WANG Li MA Lan LI Cong TENG Li-rong.Apoptotic Effects of Hypocrellin A on HeLa Cells[J].Chemical Research in Chinese University,2006,22(6):772-775. | |
| Authors: | Xiao-fang FEI Jie CHEN Ke-yan ZHENG Wei WU Su-juan SUN Li WANG Lan MA Cong LI Li-rong TENG |
| Institution: | aCollege of Life Sciences, Jilin University, Changchun 130012, P. R. China bKey Laboratory of Excited State Physics Process, Chinese Academy of Sciences, Changchun 130022, P. R. China cDepartment of Chemistry, Jilin University, Changchun 130012, P. R. China dChangchun Terumo Medical Products Co., Ltd., Changchun 130000, P. R. China eJilin Province Xidian Pharmaceutical Sci-tech Development Co., Ltd., Changchun 130000, P. R. China fDepartment of Biology, Yunnan University, Kunming 650091, P. R. China gDepartment of Chemistry, Yunnan University, Kunming 650091, P. R. China |
| Abstract: | Hypocrellin A(HA), a photosensitive perylenequinone compound of Hypocrella bambusae, inhibited the prolife-{ration} of several tumor cell lines. Human cervical cancer cells, HeLa cells, were used as a model to elucidate the molecular mechanisms of HA-induced tumor cell death. The results show that HA can induce the oligonucleosomal fragmentation of DNA in HeLa cells and also can increase the expression of apoptosis inducer Bax mRNA and that it decreases the expression of apoptosis suppressor, Bcl-2 mRNA, in mitochondria. It can be concluded from the data that HA-induced apoptosis is related to the balance between Bcl-2 and Bax gene expressions. |
| Keywords: | Hypocrellin A Hypocrella bambusae HeLa cells Apoptotic effect |
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