Toward the synthesis of spirastrellolide a: construction of a tetracyclic C26-C40 subunit containing the DEF-bis-spiroacetal |
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| Authors: | Paterson Ian Anderson Edward A Dalby Stephen M Loiseleur Olivier |
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| Institution: | University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. ip100@cam.ac.uk |
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| Abstract: | reaction: see text] A stereo-controlled synthesis of the fully elaborated C26-C40 tricyclic 5,6,6]-bis-spiroacetal of spirastrellolide A containing the C28 chlorine substituent is reported, exploiting asymmetric Sharpless dihydroxylation and boron-mediated allylation methodology. |
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