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Double reductive cyclization: a facile synthesis of the indoloquinoline alkaloid cryptotackieine
Authors:P.T. Parvatkar  P.S. Parameswaran  S.G. Tilve
Affiliation:a National Institute of Oceanography, Dona Paula, Goa 403 207, India
b Department of Chemistry, Goa University, Taleigao Plateau, Goa 403 206, India
Abstract:A new synthesis of the indoloquinoline alkaloid cryptotackieine, isolated from Cryptolepis sanguinolenta, is described which involves a Perkin reaction, a tandem double reduction-double cyclization reaction followed by regioselective methylation at the quinoline nitrogen.
Keywords:Indoloquinoline alkaloid   Perkin reaction   Cryptotackieine   Neocryptolepine   Tandem   Reductive cyclization
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