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Concise total syntheses of heliannuols B and D |
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| Authors: | Yuki Manabe Makoto KanematsuMasahiro Yoshida Kozo Shishido |
| Institution: | Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505, Japan |
| Abstract: | Concise and efficient enantioselective total syntheses of heliannuols B and D have been accomplished using chirality transfer through a Lewis acid-promoted Claisen rearrangement for the construction of the C7 tertiary stereogenic center and a relay ring-closing metathesis for assembling the dihydrobenzob]oxepine backbone of the natural products as the key steps. |
| Keywords: | Total synthesis Sesquiterpenoids Relay ring-closing metathesis Diastereoselectivity Claisen rearrangement |
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