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A divergent approach for the synthesis of some polyhydroxy pyrrolidines and piperidines from ribosylamine
Authors:Sahadev S. Chirke  Anugula RajenderBatchu Venkateswara Rao
Affiliation:Organic and Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India
Abstract:A simple and efficient synthesis of 1,4-dideoxy-1,4-imino-d-ribitol, 1,4-dideoxy-1,4-imino-l-lyxitol, N-benzyl derivative of d-ribitol, 3,4,5-trihydroxy-piperidine, l-4-epi-isofagomine and d-3-epi-isofagomine, which are glycosidase inhibitors has been described from the commercially available d-ribose as a starting material.
Keywords:Iminosugar   Glucosidase inhibitor   Isofagomine derivatives   Reduction   5-exo-tet Epoxide opening
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