Brønsted acid-assisted N-alkylation of sulfonamides using ethers as the alkylation reagents |
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| Authors: | Wei Shi Chun-Mei Bai Kai Zhu Dong-Mei Cui Chen Zhang |
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| Institution: | 1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China;2. School of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China |
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| Abstract: | N-Alkylation of sulfonamides using cyclic ethers as alkylation reagents and Brønsted acid as a catalyst produced pyrrolidine and piperidine derivatives in good yields. When using symmetrical and unsymmetrical ethers as alkylation reagents, mono-N-alkylation of sulfonamides took place to afford the corresponding products. |
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| Keywords: | N-Alkylation Sulfonamide Brø nsted acid Ether Pyrrolidine |
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