Mild and direct conversion of esters to morpholine amides using diisobutyl(morpholino)aluminum: application to efficient one-pot synthesis of ketones and aldehydes from esters |
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Authors: | Ah Ram Jeon Min Eai KimJae Kyo Park Won Kyu ShinDuk Keun An |
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Institution: | Department of Chemistry, Kangwon National University, and Institute for Molecular Science and Fusion Technology, Chuncheon 200-701, Republic of Korea |
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Abstract: | Morpholine amide intermediates, which are easily prepared by aminolysis of various esters with diisobutyl(morpholino)aluminum, react with organolithium and reducing agents (DIBALH or LDBMA) without isolation of the aminolysis intermediates to give ketones in 83–95% yields and aldehydes quantitatively. |
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Keywords: | Morpholine amide Diisobutyl(morpholino)aluminum Ester Ketone Aldehyde |
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