Synthesis and characterization of a new lanthanide based MRI contrast agent,potential and versatile tracer for multimodal imaging |
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Authors: | Satya Narayana Murthy Chilla Sophie Laurent Luce Vander Elst Robert N. Muller |
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Affiliation: | 1. Department of General, Organic and Biomedical Chemistry NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau, 19, Mendeleiev Building, 7000 Mons, Belgium;2. Centre for Microscopy and Molecular Imaging (CMMI), Rue Adrienne Bolland 8, 6041 Charleroi-Gosselies, Belgium |
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Abstract: | In the present work a modular pathway towards the synthesis of a new versatile MRI contrast agent is reported and its physico-chemical properties are described. Two different functional groups were attached on two arms of the gadolinium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA) in order to get a platform able to bind one probe designed to target specific biological marker and a fluorescent molecule likely to be used for optical imaging. The nuclear magnetic relaxation dispersion (NMRD) profile, the oxygen-17 relaxometric NMR study and stability assessment versus transmetalation of the Gd-complex show that this new contrast agent has a relaxivity and transmetalation stability similar to Gd–DOTA. |
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Keywords: | Imaging agents Macrocyclic ligands Gadolinium Relaxivity Gd&ndash DOTA |
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