An efficient,three-component synthesis and molecular structure of derivatives of 2-amino-3-R-6-ethyl-4,6-dihydropyrano[3,2-c][2,1]benzothiazine-5,5-dioxide spirocombined with a 2-oxindole nucleus |
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| Authors: | Leonid A. Shemchuk Dmitry A. Lega Ruslan Gr. Redkin Valentin P. Chernykh Oleg V. Shishkin Svetlana V. Shishkina |
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| Affiliation: | 1. National University of Pharmacy, Pushkinska Str. 53, Kharkiv 61001, Ukraine;2. STC Institute for Single Crystals, National Academy of Sciences of Ukraine, Lenin Ave. 60, Kharkiv 61001, Ukraine |
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| Abstract: | Spiro[(2-amino-3-R-6-ethyl-4,6-dihydropyrano[3,2-c][2,1]benzothiazine-5,5-dioxide)-4,3′-(1′-R′-5′-R″-indolin-2′-one)] compounds were synthesized based on the three-component interaction of benzo[c][2,1]thiazin-4-on 2,2-dioxide with corresponding isatins and appropriate methylene active nitriles in the presence of a base as a catalyst. The molecular structures of the target compounds were proved uniquely by the X-ray diffraction analysis method. |
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| Keywords: | Benzo[c][2,1]thiazine 2-Oxindoles Methylene active nitriles Spirocyclic compounds 4,6-Dihydropyrano[3,2-c][2,1]benzothiazine-5,5-dioxide X-ray diffraction analysis |
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