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Copper-catalyzed aerobic oxidative dehydrogenation for conversion of 2-(alkylthio)-1,4-dihydropyrimidines to 2-(alkylthio)pyrimidines
Authors:Nguyen Huu Trong Phan  Jeong-Hun Sohn
Affiliation:Department of Chemistry, College of Natural Sciences, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 305-764, Republic of Korea
Abstract:A simple and efficient aerobic oxidative dehydrogenation reaction method for the conversion of 2-(alkylthio)-1,4-dihydropyrimidines to 2-(alkylthio)pyrimidines using copper catalyst with no additives, such as an oxidant, acid, or base, has been developed. The reaction was successful with a wide range of 2-(alkylthio)-1,4-dihydropyrimidine substrates.
Keywords:Aerobic oxidation   Dehydrogenation   Dihydropyrimidine   Pyrimidine   Copper catalyzed oxidation
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