An efficient one-pot synthesis of 1,2,4-triazoloquinoxalines |
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| Authors: | Xiaoyi Niu Bingchuan Yang Shuai Fang Yanqiu Li Zeyuan Zhang Jiong Jia Chen Ma |
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| Institution: | 1. Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, 250100 Jinan, PR China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China |
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| Abstract: | A transition metal-free tandem process for the synthesis of 1,2,4-triazoloquinoxalines was described. The construction of this tricyclic system went through a one-pot condensation/nucleophilic aromatic substitution approach. This methodology applied to a broad range of substrates, which included 2-halogenated or 2-nitro aryl aldehydes and ketones. |
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| Keywords: | 1 2 4-Triazoloquinoxaline One-pot synthesis Transition metal-free Broad range of substrates |
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