Three-component domino reaction synthesis of highly functionalized bicyclic pyrrole derivatives |
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| Authors: | Xue-Bing Chen Xiao-Ying WangDan-Dan Zhu Sheng-Jiao Yan Jun Lin |
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| Affiliation: | Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China |
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| Abstract: | An efficient one-pot synthesis of highly functionalized bicyclic pyrrole derivatives by a three-component domino reaction of heterocyclic ketene aminals (HKAs), arylglyoxal monohydrate, and indoles in ethanol medium catalyzed by acetic acid is described. In this procedure, three sigma bonds were formed simultaneously. The present synthesis features excellent regio-selectivity, easy purification as well as simple starting materials. |
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| Keywords: | Bicyclic pyrroles Heterocyclic ketene aminals Three-component Domino reaction |
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