Iodine(III)-mediated ethoxychlorination of enamides with iron(III) chloride |
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| Authors: | Sophie Nocquet-Thibault Corinne MinardPascal Retailleau Kevin CariouRobert H. Dodd |
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| Affiliation: | Centre de Recherche de Gif-sur-Yvette, Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France |
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| Abstract: | The combination of (diacetoxyiodo)benzene and iron(III) chloride in ethanol allows the efficient regioselective ethoxychlorination of a broad range of enamides. Mechanistic studies tend to rule out the involvement of free radical species and point towards the implication of a mixed [chloro(ethoxy)iodo]benzene intermediate. |
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| Keywords: | Hypervalent iodine Umpolung Chlorination Enamides |
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