Atom-economical isocyanide-based multicomponent synthesis of 2,5-dioxopyrrolidines,spirobenzothiazinechromans and 1,5-benzothiazepines |
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| Authors: | Roya Akbarzadeh Tayebeh AmanpourHamid Reza Khavasi Ayoob Bazgir |
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| Institution: | Department of Chemistry, Shahid Beheshti University, General Campus, Tehran 1983963113, Iran |
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| Abstract: | An efficient synthesis of new pharmaceutically relevant dioxopyrrolidines, spirobenzo thiazine-2,3′-chromans, and benzothiazepines via isocyanide-based multicomponent condensation reactions at room temperature is reported. This synthesis serves as a nice addition to group-assistant-purification (GAP) chemistry in which purification via chromatography and recrystallization can be avoided, and the pure products are obtained simply by washing the crude products with 95% ethanol. |
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| Keywords: | Isocyanide Dioxopyrrolidine Spirobenzothiazine-2 3&prime -chroman Benzothiazepines |
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