A mild,copper-catalysed amide deprotection strategy: use of tert-butyl as a protecting group |
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Authors: | Vikki Evans Mary F. MahonRuth L. Webster |
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Affiliation: | University of Bath, Claverton Down, Bath BA2 7AY, UK |
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Abstract: | Mild methods for the deprotection of organic substrates are of fundamental importance in synthetic chemistry. A new room temperature method using a catalytic amount of Cu(OTf)2 is reported. This allows use of the tert-butyl group as an amide protecting group. The methodology is also extended to Boc-deprotection. |
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Keywords: | Amides Deprotection Catalysis Copper |
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