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Copper-mediated trifluoromethylation of potassium alkynyltrifluoroborates with Langlois' reagent |
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| Authors: | Srinivas Reddy Dubbaka Shashidhar NizalapurAzmi Reddy Atthunuri Manohar SallaThresen Mathew |
| Institution: | Department of Medicinal Chemistry, Albany Molecular Research Singapore Research Centre, Pte Ltd, 61 Science Park Road, #05-01 Galen, Science Park II, Singapore 117525, Singapore |
| Abstract: | Synthesis of trifluoromethylated acetylenes by copper-mediated trifluoromethylation of potassium alkynyltrifluoroborates with CF3 radicals generated from NaSO2CF3 and tert-butyl hydroperoxide (TBHP) is communicated. The trifluoromethylated acetylenes were obtained in good to moderate yields. The presented method tolerates a wide range of aromatic, heteroaromatic, and aliphatic potassium alkynyltrifluoroborates. |
| Keywords: | Terminal alkynes Trifluoromethylation Potassium alkynyltrifluoroborates Copper Langlois' reagent |
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