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Formamidobisabolene-based derivatives from a sponge Axinyssa sp. |
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| Authors: | Wei Cheng Dong Liu Fengying Zhang Qingying Zhang Patchara Pedpradab Peter Proksch Hong Liang Wenhan Lin |
| Institution: | 1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, PR China;2. Department of Marine Science, Rajamangala University of Technology Srivijaya, 92150 Trang, Thailand;3. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Duesseldorf, Germany |
| Abstract: | Chemical examination of a Chinese sponge Axinyssa sp. resulted in the isolation of 12 new formamidobisabolene-based analogues named axinyssines A–L (1–12), along with a new natural product (13) and three known formamidobisabolenes (14–16). Their structures were determined on the basis of extensive NMR and mass spectroscopic analyses in association with ICD data, Mosher reaction and chemical conversion for the assignment of absolute configurations. All compounds were evaluated for antitumor and antimicrobial activities. |
| Keywords: | Sponge Axinyssa sp Formamidobisabolenes Structural elucidation Antimicrobial activities |
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