FeCl3-catalyzed three-component reaction: a novel synthesis of tetrahydro-2,6-dioxopyrimidin-4-yl-2,3-dihydrophthalazine-1,4-dione derivatives under solvent-free conditions |
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Authors: | Veeranarayana Reddy Mudumala Radha Rani Chinthaparthi Tae Jeong Yeon |
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Affiliation: | 1. Department of Image Science and Engineering, Pukyong National University, Busan 608-737, Republic of Korea;2. Department of Chemistry, Sri Venkateswara University, Tirupati 517502, India |
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Abstract: | Three-component coupling of phthalhydrazide, aldehydes, and barbituric acid has been accomplished in the presence of 15 mol % FeCl3 under solvent-free conditions to afford the corresponding tetrahydro-2,6-dioxopyrimidin-4-yl)-2,3-dihydrophthalazine-1,4-dione derivatives in excellent yields. This method provides high yields, shorter reaction time, and mild reaction conditions. This is the first example of the condensation of phthalhydrazide, aldehydes, and barbituric acid to provide a novel series of phthalhydrazide derivatives. |
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Keywords: | Tetrahydro-2,6-dioxopyrimidin-4-yl)-2,3-dihydrophthalazine-1,4-dione derivatives FeCl3 Neat condition Barbituric acid |
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