Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana |
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| Authors: | Yoshinori Saito Yoko Sasaki Teppei Komiyama Ayumi Ohsaki Yasuko Okamoto Xun Gong Chiaki Kuroda Motoo Tori |
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| Affiliation: | 1. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan;2. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan;3. Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, China;4. Department of Chemistry and Research Center for Smart Molecules, Rikkyo University, Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501, Japan |
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| Abstract: | Five new 12-oxygenated eremophilane sesquiterpenoids bearing a B-ring enone system were isolated from Ligularia lingiana S.W. Liu (Asteraceae) collected in China. Compound 5 was a Diels–Alder adduct of 3α-angeloyloxy-7βH-8-oxoeremophila-9,11(13)-dien-12-al and the monoterpene, ocimene. Compound 1 showed cytotoxic activities against HeLa, HL60, Jurkat, and NIH-3T3 cells at IC50 0.0407, 0.440, 0.313, and 3.48 μM, respectively. |
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| Keywords: | Asteraceae Ligularia lingiana Sesquiterpenoid Eremophilane Dimer |
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