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Scalable synthesis of (−)-trans-3-hydroxypipecolic acid via a useful chiral building block |
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| Authors: | Oskari K. Karjalainen Ari M.P. Koskinen |
| Affiliation: | Aalto University School of Chemical Technology, Kemistintie 1, 02150 Espoo, Finland |
| Abstract: | A scalable synthesis of (−)-trans-2-(hydroxymethyl)-1,2,3,6-tetrahydropyridin-3-ol, a versatile chiral building block is described along with its transformation to (−)-trans-3-hydroxypipecolic acid. |
| Keywords: | Amino alcohol Diastereoselective synthesis Hydroxypipecolic acid |
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