Highly efficient synthesis of polysubstituted 1,2-dihydroquinolines via cascade reaction of α-ketoesters with arylamines mediated by iodine |
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Authors: | Bao-Qiang Zhang Yuan LuoYan-Hong He Zhi Guan |
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Institution: | School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China |
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Abstract: | An efficient strategy enabling the construction of polysubstituted 1,2-dihydroquinoline derivatives mediated by the commercially available, economical, and environmentally benign iodine (3 mol %) under mild conditions was developed. Various arylamines and α-ketoesters could participate in this cascade reaction, and the desired products were obtained in excellent yields up to 98%. |
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Keywords: | Polysubstituted 1 2-dihydroquinoline α-Ketoester Arylamine Iodine Cascade reaction |
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