T3P-assisted esterification and amidation of phosphinic acids |
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| Authors: | Erzsé bet Jablonkai,Ré ka Henyecz,Má tyá s Milen,Já nos Kó ti,Gyö rgy Keglevich |
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| Affiliation: | 1. Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary;2. API Research and Development, Spectroscopic Research, Gedeon Richter Plc., 1475 Budapest, Hungary |
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| Abstract: | A few phosphinic acids, such as phenylphosphinic acids, 1-hydroxy-3-phospholene 1-oxides and 1-hydroxyphospholane oxides are esterified with simple alcohols in the presence of propylphosphonic anhydride (T3P®). If 1.1 equiv of the T3P® reagent is used, the esterifications are fast and efficient at 25° C. In the case of more reactive models it was enough to apply 0.66 equiv of T3P® at 85° C under microwave conditions. The amidation of 1-hydroxy-3-methyl-3-phospholene oxide could also be accomplished under similar conditions. |
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| Keywords: | Phosphinic acid Phosphinic amide P-Heterocycles Phosphinate T3P® reagent Green synthesis |
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