Synthesis and evaluation of N6-substituted azide- and alkyne-bearing N-mustard analogs of S-adenosyl-l-methionine |
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| Authors: | Mohamed Ramadan Natalie K. Bremner-HaySteig A. Carlson Lindsay R. Comstock |
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| Affiliation: | Department of Chemistry, Wake Forest University, Winston-Salem, NC 27106, USA |
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| Abstract: | The synthesis of a family of N-mustard analogs of S-adenosyl-l-methionine (SAM) containing azides and alkynes at the N6-position of the adenosine base has been accomplished from commercially available inosine. Further biochemical analysis of these analogs indicates successful modification of pUC19 plasmid DNA in an enzyme-dependent fashion with DNA methyltransferases M.TaqI and M.HhaI. |
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| Keywords: | S-Adenosyl-l-methionine DNA methyltransferase SAM analog N-Mustard |
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