|
|||||
|
|
Development of the 8-aza-3-bromo-7-hydroxycoumarin-4-ylmethyl group as a new entry of photolabile protecting groups |
|
| Authors: | Hikaru Takano Tetsuo Narumi Nami Ohashi Akinobu Suzuki Toshiaki Furuta Wataru Nomura Hirokazu Tamamura |
| Institution: | 1. Institution of Biomaterial and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan;2. Department of Biomolecular Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan |
| Abstract: | A significant substitution effect of the position of the bromo group on the photosensitivity of the 8-azacoumarin chromophore leads to the development of a highly photosensitive 8-aza-3-bromo-7-hydroxycoumarin-4-ylmethyl (aza-3-Bhc) group that shows excellent photolytic efficiency and hydrophilicity with long-wavelength absorption maxima. The newly identified aza-3-Bhc group can be applied to caged glutamates for ester-type and carbamate-type protections of carboxyl and amino functionalities. |
| Keywords: | Azacoumarin Photolabile protecting groups Caged compounds Photolytic efficiency Hydrophilicity |
| 本文献已被 ScienceDirect 等数据库收录！ | |