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Synthesis and evaluation of new caged compound with thiochromone derivative |
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| Authors: | Yasuo Sasaki Ryo SugiuraYasuhiro Nishiyama Hiroki TanimotoTsumoru Morimoto Kiyomi Kakiuchi |
| Affiliation: | Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama, Ikoma, Nara 630-0101, Japan |
| Abstract: | A new caged firefly luciferin (luciferin) with a thiochromone S,S-dioxide (TSSDO) as a photolabile protecting group was synthesized. Photodeprotection of the caged compound proceeded smoothly under photoirradiation at 365 nm in aqueous solution. The bioluminescence of the regenerated luciferin after uncaging was detected using a typical luciferin–luciferase reaction. These results indicated that TSSDO could be an attractive chemical tool for regulating biological phenomena. |
| Keywords: | Caged compound Thiochromone Luciferin&ndash luciferase reaction Fluorescence Photolabile protecting group |
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