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Substrate scope in the direct imine acylation of ortho-substituted benzoic acid derivatives: the total synthesis (±)-cavidine |
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| Authors: | Christiana Kitsiou William P UnsworthGraeme Coulthard Richard JK Taylor |
| Institution: | University of York, Heslington, York YO10 5DD, UK |
| Abstract: | The direct imine acylation (DIA) and subsequent cyclisation of a range of imines with ortho-substituted benzoic acid derivatives is described. Variation in the coupling reagents, imine and benzoic acid were all examined. The DIA procedure was also applied in the total synthesis of (±)-cavidine. |
| Keywords: | N-Acyliminium ions Nitrogen heterocycles Molecular diversity Cavidine Evodiamine |
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