DMAP-catalyzed four-component one-pot synthesis of highly functionalized spirooxindole-1,4-dihydropyridines derivatives in aqueous ethanol |
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Authors: | Chao Han Wei Meng Hao Liu Yanping Liu Jingchao Tao |
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Institution: | 1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052, Henan, PR China;2. College of Chemical Engineering, Hebei United University, Tangshan 063009, Hebei, PR China;3. College of Engineering Technology, Zhongzhou University, Zhengzhou 450052, Henan, PR China |
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Abstract: | An efficient, clean, and environmental friendly ‘one-pot’ four-component reaction was developed for assembling a novel type of spirooxindole derivatives containing dihydropyridine and pyrrolidinone. The reaction could be easily performed in aqueous ethanol with 4-DMAP as catalyst in good yields. The high efficiency and the simple and mild condition of the reaction, in addition with its avoidance of time-consuming, costly syntheses, and tedious workup, endowed the reaction with application significance. A series of spirooxindole derivatives were therefore prepared in excellent yields by using this ‘one-pot’ four-component reaction method. |
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Keywords: | &lsquo One-pot&rsquo four-component reaction Spirooxindole derivatives DMAP Tetramic acid 1 4-Dihydropyridine |
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